Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats

Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty determining the biological relevance of reduction in fetal testosterone (T) on postnatal development. The objectives of the current study were 2-fold:...

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Pubblicato in:Toxicol Sci
Autori principali: Howdeshell, Kembra L., Rider, Cynthia V., Wilson, Vickie S., Furr, Johnathan R., Lambright, Christy R., Gray, L. Earl
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Modeling Phthalate Effects on Testosterone and Male Reproductive Tract
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4675932/
https://ncbi.nlm.nih.gov/pubmed/26350170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv196
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