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How genome complexity can explain the difficulty of aligning reads to genomes

BACKGROUND: Although it is frequently observed that aligning short reads to genomes becomes harder if they contain complex repeat patterns, there has not been much effort to quantify the relationship between complexity of genomes and difficulty of short-read alignment. Existing measures of sequence...

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Publicat a:BMC Bioinformatics
Autors principals: Phan, Vinhthuy, Gao, Shanshan, Tran, Quang, Vo, Nam S
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674900/
https://ncbi.nlm.nih.gov/pubmed/26678826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-16-S17-S3
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