miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity

microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO) proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite their importance in many biological processes, rules governing AGO–miRNA targeting are only partially understood. Here we report a modified A...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Moore, Michael J., Scheel, Troels K. H., Luna, Joseph M., Park, Christopher Y., Fak, John J., Nishiuchi, Eiko, Rice, Charles M., Darnell, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674787/
https://ncbi.nlm.nih.gov/pubmed/26602609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9864
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