STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

Haematopoietic stem cells (HSCs) require the right composition of microRNAs (miR) for proper life-long balanced blood regeneration. Here we show a regulatory circuit that prevents excessive HSC self-renewal by upregulation of miR-193b upon self-renewal promoting thrombopoietin (TPO)-MPL-STAT5 signal...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Haetscher, Nadine, Feuermann, Yonatan, Wingert, Susanne, Rehage, Maike, Thalheimer, Frederic B., Weiser, Christian, Bohnenberger, Hanibal, Jung, Klaus, Schroeder, Timm, Serve, Hubert, Oellerich, Thomas, Hennighausen, Lothar, Rieger, Michael A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Pub. Group 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674773/
https://ncbi.nlm.nih.gov/pubmed/26603207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9928
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