p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

Centriolar satellites (CS) are small granular structures that cluster in the vicinity of centrosomes. CS are highly susceptible to stress stimuli, triggering abrupt displacement of key CS factors. Here we discover a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trigger...

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Udgivet i:Nat Commun
Main Authors: Tollenaere, Maxim A. X., Villumsen, Bine H., Blasius, Melanie, Nielsen, Julie C., Wagner, Sebastian A., Bartek, Jiri, Beli, Petra, Mailand, Niels, Bekker-Jensen, Simon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674683/
https://ncbi.nlm.nih.gov/pubmed/26616734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10075
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