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Development of Novel Chitosan Microcapsules for Pulmonary Delivery of Dapsone: Characterization, Aerosol Performance, and In Vivo Toxicity Evaluation

Pneumocystis carinii pneumonia (PCP) is a major opportunistic infection that affects patients with human immunodeficiency virus. Although orally administered dapsone leads to high hepatic metabolism, decreasing the therapeutic index and causing severe side effects, this drug is an effective alternat...

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Bibliografiske detaljer
Udgivet i:AAPS PharmSciTech
Main Authors: Ortiz, Manoel, Jornada, Denise Soledade, Pohlmann, Adriana Raffin, Guterres, Sílvia Stanisçuaski
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674640/
https://ncbi.nlm.nih.gov/pubmed/25652730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-015-0283-3
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