Development of Novel Chitosan Microcapsules for Pulmonary Delivery of Dapsone: Characterization, Aerosol Performance, and In Vivo Toxicity Evaluation

Pneumocystis carinii pneumonia (PCP) is a major opportunistic infection that affects patients with human immunodeficiency virus. Although orally administered dapsone leads to high hepatic metabolism, decreasing the therapeutic index and causing severe side effects, this drug is an effective alternat...

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Dettagli Bibliografici
Pubblicato in:AAPS PharmSciTech
Autori principali: Ortiz, Manoel, Jornada, Denise Soledade, Pohlmann, Adriana Raffin, Guterres, Sílvia Stanisçuaski
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674640/
https://ncbi.nlm.nih.gov/pubmed/25652730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-015-0283-3
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