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Destabilizing RET in targeted treatment of thyroid cancers
Metastatic differentiated thyroid cancers (DTC) are resistant to traditional chemotherapy. Kinase inhibitors have shown promise in patients with progressive DTC, but dose-limiting toxicity is commonplace. HSP90 regulates protein degradation of several growth-mediating kinases such as RET, and we hyp...
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| Publicado en: | Endocr Connect |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Bioscientifica Ltd
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4674629/ https://ncbi.nlm.nih.gov/pubmed/26574568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-15-0098 |
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