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Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients

Large size, protein binding and intracellular sequestration are well known to limit dialytic removal of compounds. In studying the normal renal and dialytic handling of trimethylamine oxide (TMAO), a molecule associated with cardiovascular disease in the general population, we discovered two largely...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Hai, Xin, Landeras, Veeda, Dobre, Mirela A., DeOreo, Peter, Meyer, Timothy W., Hostetter, Thomas H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674074/
https://ncbi.nlm.nih.gov/pubmed/26650937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143731
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