Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients

Large size, protein binding and intracellular sequestration are well known to limit dialytic removal of compounds. In studying the normal renal and dialytic handling of trimethylamine oxide (TMAO), a molecule associated with cardiovascular disease in the general population, we discovered two largely...

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Udgivet i:PLoS One
Main Authors: Hai, Xin, Landeras, Veeda, Dobre, Mirela A., DeOreo, Peter, Meyer, Timothy W., Hostetter, Thomas H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674074/
https://ncbi.nlm.nih.gov/pubmed/26650937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143731
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