TDP1 promotes assembly of non-homologous end joining protein complexes on DNA

The repair of DNA double-strand breaks (DSB) is central to the maintenance of genomic integrity. In tumor cells, the ability to repair DSBs predicts response to radiation and many cytotoxic anti-cancer drugs. DSB repair pathways include homologous recombination and non-homologous end joining (NHEJ)....

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Heo, Jinho, Li, Jing, Summerlin, Matthew, Hays, Annette, Katyal, Sachin, McKinnon, Peter J., Nitiss, Karin C., Nitiss, John L., Hanakahi, Leslyn A.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673895/
https://ncbi.nlm.nih.gov/pubmed/25841101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.03.003
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