Chloride–hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro

Osteoblasts form an epithelium-like layer with tight junctions separating bone matrix from extracellular fluid. During mineral deposition, calcium and phosphate precipitation in hydroxyapatite liberates 0.8 mole of H(+) per mole Ca(+2). Thus, acid export is needed for mineral formation. We examined...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Larrouture, Quitterie C, Nelson, Deborah J, Robinson, Lisa J, Liu, Li, Tourkova, Irina, Schlesinger, Paul H, Blair, Harry C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673636/
https://ncbi.nlm.nih.gov/pubmed/26603451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12607
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