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Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response
Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variatio...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4673606/ https://ncbi.nlm.nih.gov/pubmed/26647780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17997 |
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