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Energetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response

Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variatio...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Paramo, Teresa, Tomasio, Susana M., Irvine, Kate L., Bryant, Clare E., Bond, Peter J.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673606/
https://ncbi.nlm.nih.gov/pubmed/26647780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17997
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