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Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway

The ability to biosynthetically produce chemicals beyond what is commonly found in Nature requires the discovery of novel enzyme function. Here we utilize two approaches to discover enzymes that enable specific production of longer-chain (C(5)–C(8)) alcohols from sugar. The first approach combines b...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Mak, Wai Shun, Tran, Stephen, Marcheschi, Ryan, Bertolani, Steve, Thompson, James, Baker, David, Liao, James C., Siegel, Justin B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673503/
https://ncbi.nlm.nih.gov/pubmed/26598135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10005
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