A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model

YM155, a small molecule inhibitor of the antiapoptotic protein survivin, has been developed as a potential anti-cancer drug. We investigated a combination therapy of YM155 and interleukin-2 (IL-2) in a mouse model of renal cell carcinoma (RCC). YM155 caused cell cycle arrest and apoptosis in renal c...

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Publicat a:Oncotarget
Autors principals: Guo, Kai, Huang, Peng, Xu, Naijin, Xu, Peng, Kaku, Haruki, Zheng, Shaobo, Xu, Abai, Matsuura, Eiji, Liu, Chunxiao, Kumon, Hiromi
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673255/
https://ncbi.nlm.nih.gov/pubmed/26023798
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