Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Several studies have demonstrated that MUC4 is involved in progression and metastasis of pancreatic cancer (PC). Here, we report that HER3/MUC4 interaction in HER2 low cells is critical in driving pancreatic tumorigenesis. Upon HER2 knockdown, we observed elevated expression of HER3 and MUC4 and the...

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Vydáno v:Oncotarget
Hlavní autoři: Lakshmanan, Imayavaramban, Seshacharyulu, Parthasarathy, Haridas, Dhanya, Rachagani, Satyanarayana, Gupta, Suprit, Joshi, Suhasini, Guda, Chittibabu, Yan, Ying, Jain, Maneesh, Ganti, Apar K., Ponnusamy, Moorthy P., Batra, Surinder K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673252/
https://ncbi.nlm.nih.gov/pubmed/26035354
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