Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy

Aneuploidy is a common feature of cancer, with human solid tumour cells typically harbouring abnormal chromosome complements. The aneuploidy observed in cancer is often caused by a chromosome instability phenotype, resulting in genomic heterogeneity. However, the role aneuploidy and chromosome insta...

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Publicat a:Oncotarget
Autors principals: Bennett, Ailsa, Bechi, Beatrice, Tighe, Anthony, Thompson, Sarah, Procter, David J., Taylor, Stephen S.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper: Chromosome
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673239/
https://ncbi.nlm.nih.gov/pubmed/26320186
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