Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect

Maintenance chemotherapy is an important part of the treatment of ALL in children. It relies on the long-term oral administration of daily low-dose mercaptopurin and weekly low-dose methotrexate. Although it has been used in the clinic for decades, its mechanisms of action remain unclear. Here, we i...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Andre, Nicolas, Cointe, Sylvie, Barlogis, Vincent, Arnaud, Laurent, Lacroix, Romaric, Pasquier, Eddy, Dignat-George, Françoise, Michel, Gérard, Sabatier, Florence
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Clinical Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673217/
https://ncbi.nlm.nih.gov/pubmed/26284583
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