The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis

The receptor activator of nuclear factor κ-B ligand (RANKL)/RANK pathway plays an important role in breast cancer progression. Despite the known role of Casitas B-lineage lymphoma (Cbl)-b as an essential regulator of the RANKL/RANK pathway, its effect on RANK pathway in breast cancer remains unclear...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Zhang, Lingyun, Teng, Yuee, Fan, Yibo, Wang, Yan, Li, Wei, Shi, Jing, Ma, Yanju, Li, Ce, Shi, Xiaonan, Qu, Xiujuan, Liu, Yunpeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673209/
https://ncbi.nlm.nih.gov/pubmed/26087197
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