Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

Hypoxia is an independent prognostic indicator of poor outcome in several malignancies. However, precise mechanism through which hypoxia promotes disease aggressiveness is still unclear. Here, we report that under hypoxia (1% O(2)), human prostate cancer (PCA) cells, and extracellular vesicles (EVs)...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Schlaepfer, Isabel R., Nambiar, Dhanya K., Ramteke, Anand, Kumar, Rahul, Dhar, Deepanshi, Agarwal, Chapla, Bergman, Bryan, Graner, Michael, Maroni, Paul, Singh, Rana P., Agarwal, Rajesh, Deep, Gagan
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673203/
https://ncbi.nlm.nih.gov/pubmed/26087400
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