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Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia

Minimal Residual Disease (MRD) detection can be used for early intervention in relapse, risk stratification, and treatment guidance. FLT3 ITD is the most common mutation found in AML patients with normal karyotype. We evaluated the feasibility of NGS with high coverage (up to 2.4.10(6) PE fragments)...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Bibault, Jean-Emmanuel, Figeac, Martin, Hélevaut, Nathalie, Rodriguez, Céline, Quief, Sabine, Sebda, Shéhérazade, Renneville, Aline, Nibourel, Olivier, Rousselot, Philippe, Gruson, Bérengère, Dombret, Hervé, Castaigne, Sylvie, Preudhomme, Claude
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673201/
https://ncbi.nlm.nih.gov/pubmed/26078355
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