Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels

To characterize the mutation profiles of colorectal cancer (CRC) primary tumors (PTs) and liver metastases (CLMs), we performed both whole-exome and RNA sequencing. Ten significantly mutated genes, including BMI1, CARD11, and NRG1, were found in 34 CRCs with CLMs. We defined three mutation classes (...

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Publicado en:Oncotarget
Autores principales: Lim, Byungho, Mun, Jihyeob, Kim, Jeong-Hwan, Kim, Chan Wook, Roh, Seon Ae, Cho, Dong-Hyung, Kim, Yong Sung, Kim, Seon-Young, Kim, Jin Cheon
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673155/
https://ncbi.nlm.nih.gov/pubmed/26109429
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