Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels

To characterize the mutation profiles of colorectal cancer (CRC) primary tumors (PTs) and liver metastases (CLMs), we performed both whole-exome and RNA sequencing. Ten significantly mutated genes, including BMI1, CARD11, and NRG1, were found in 34 CRCs with CLMs. We defined three mutation classes (...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Lim, Byungho, Mun, Jihyeob, Kim, Jeong-Hwan, Kim, Chan Wook, Roh, Seon Ae, Cho, Dong-Hyung, Kim, Yong Sung, Kim, Seon-Young, Kim, Jin Cheon
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673155/
https://ncbi.nlm.nih.gov/pubmed/26109429
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