Human CD4(+) T cells require exogenous cystine for glutathione and DNA synthesis

Adaptive immune responses require activation and expansion of antigen-specific T cells. Whereas early T cell activation is independent of exogenous cystine (Cys(2)), T cell proliferation is dependent of Cys(2). However, the exact roles of Cys(2) in T cell proliferation still need to be determined. T...

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Publicado en:Oncotarget
Autores principales: Levring, Trine B., Kongsbak, Martin, Rode, Anna K. O., Woetmann, Anders, Ødum, Niels, Bonefeld, Charlotte Menné, Geisler, Carsten
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673131/
https://ncbi.nlm.nih.gov/pubmed/26392411
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