Vitamin D Up-Regulates the Vitamin D Receptor by Protecting It from Proteasomal Degradation in Human CD4(+) T Cells

The active form of vitamin D(3), 1,25(OH)(2)D(3), has significant immunomodulatory properties and is an important determinant in the differentiation of CD4(+) effector T cells. The biological actions of 1,25(OH)(2)D(3) are mediated by the vitamin D receptor (VDR) and are believed to correlate with t...

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Detalhes bibliográficos
Main Authors: Kongsbak, Martin, von Essen, Marina R., Boding, Lasse, Levring, Trine B., Schjerling, Peter, Lauritsen, Jens P. H., Woetmann, Anders, Ødum, Niels, Bonefeld, Charlotte M., Geisler, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4008591/
https://ncbi.nlm.nih.gov/pubmed/24792400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096695
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