Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly

Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. Here we report the first crystal structure of the pre-fusion f...

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Pubblicato in:PLoS Pathog
Autori principali: Xu, Kai, Chan, Yee-Peng, Bradel-Tretheway, Birgit, Akyol-Ataman, Zeynep, Zhu, Yongqun, Dutta, Somnath, Yan, Lianying, Feng, YanRu, Wang, Lin-Fa, Skiniotis, Georgios, Lee, Benhur, Zhou, Z. Hong, Broder, Christopher C., Aguilar, Hector C., Nikolov, Dimitar B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672880/
https://ncbi.nlm.nih.gov/pubmed/26646856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005322
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