A Novel Receptor-induced Activation Site in the Nipah Virus Attachment Glycoprotein (G) Involved in Triggering the Fusion Glycoprotein (F)

Cellular entry of paramyxoviruses requires the coordinated action of both the attachment (G/H/HN) and fusion (F) glycoproteins, but how receptor binding activates G to trigger F-mediated fusion during viral entry is not known. Here, we identify a receptor (ephrinB2)-induced allosteric activation sit...

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Detalhes bibliográficos
Main Authors: Aguilar, Hector C., Ataman, Zeynep Akyol, Aspericueta, Vanessa, Fang, Angela Q., Stroud, Matthew, Negrete, Oscar A., Kammerer, Richard A., Lee, Benhur
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615506/
https://ncbi.nlm.nih.gov/pubmed/19019819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807469200
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