Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

Human β-defensin 3 (hBD3) is a cationic host defence peptide and is part of the innate immune response. HBD3 is present on a highly copy number variable block of six β-defensin genes, and increased copy number is associated with the autoimmune disease psoriasis. It is not known how this increase inf...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Semple, Fiona, MacPherson, Heather, Webb, Sheila, Kilanowski, Fiona, Lettice, Laura, McGlasson, Sarah L., Wheeler, Ann P., Chen, Valerie, Millhauser, Glenn L., Melrose, Lauren, Davidson, Donald J., Dorin, Julia R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672878/
https://ncbi.nlm.nih.gov/pubmed/26646717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005673
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