Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination

Switched antibody classes are important for efficient immune responses. Aberrant antibody production to otherwise harmless antigens may result in autoimmunity. The protein kinase fms-like tyrosine kinase 3 receptor (Flt3) has an important role during early B-cell development, but the role of Flt3 in...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Svensson, Mattias N. D., Andersson, Karin M. E., Wasén, Caroline, Erlandsson, Malin C., Nurkkala-Karlsson, Merja, Jonsson, Ing-Marie, Brisslert, Mikael, Bemark, Mats, Bokarewa, Maria I.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672832/
https://ncbi.nlm.nih.gov/pubmed/26627255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514191112
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