Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism

Mammals detect and discriminate numerous odors via a large family of G protein-coupled odorant receptors (ORs). However, little is known about the molecular and structural basis underlying OR response properties. Using site-directed mutagenesis and computational modeling, we studied ORs sharing high...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Yu, Yiqun, de March, Claire A., Ni, Mengjue J., Adipietro, Kaylin A., Golebiowski, Jérôme, Matsunami, Hiroaki, Ma, Minghong
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672800/
https://ncbi.nlm.nih.gov/pubmed/26627247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517510112
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