A ceRNA approach may unveil unexpected contributors to deletion syndromes, the model of 5q- syndrome

In genomic deletions, gene haploinsufficiency might directly configure a specific disease phenotype. Nevertheless, in some cases no functional association can be identified between haploinsufficient genes and the deletion-associated phenotype. Transcripts can act as microRNA sponges. The reduction o...

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Bibliographic Details
Published in:Oncoscience
Main Authors: Arancio, Walter, Genovese, Swonild Ilenia, Bongiovanni, Lucia, Tripodo, Claudio
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
Subjects:
Research Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671954/
https://ncbi.nlm.nih.gov/pubmed/26682279
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