Leukemia-associated cohesin mutants dominantly enforce stem cell programs and impair human hematopoietic progenitor differentiation

Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex func...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Mazumdar, Claire, Shen, Ying, Xavy, Seethu, Zhao, Feifei, Reinisch, Andreas, Li, Rui, Corces-Zimmerman, M. Ryan, Flynn, Ryan A., Buenrostro, Jason D., Chan, Steven M., Thomas, Daniel, Koenig, Julie L., Hong, Wan-Jen, Chang, Howard Y., Majeti, Ravindra
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671831/
https://ncbi.nlm.nih.gov/pubmed/26607380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.09.017
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