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A 3′ poly(A) tract is required for LINE-1 retrotransposition

L1 retrotransposons express proteins (ORF1p and ORF2p) that preferentially mobilize their encoding RNA in cis, but they also can mobilize Alu RNA and, more rarely, cellular mRNAs in trans. Although these RNAs differ in sequence, each ends in a 3′ polyadenosine (poly(A)) tract. Here, we replace the L...

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發表在:Mol Cell
Main Authors: Doucet, Aurélien J., Wilusz, Jeremy E., Miyoshi, Tomoichiro, Liu, Ying, Moran, John V.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671821/
https://ncbi.nlm.nih.gov/pubmed/26585388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.012
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