CD5L/AIM regulates lipid biosythesis and restrains Th17 cell pathogenicity

Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis, but can induce autoimmunity. The mechanisms implicated in balancing ‘pathogenic’ and ‘non-pathogenic’ Th17 cell states remain largely unknown. We used single-cell RNA-seq to identify CD5L/AIM as a...

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Publicado no:Cell
Main Authors: Wang, Chao, Yosef, Nir, Gaublomme, Jellert, Wu, Chuan, Lee, Youjin, Clish, Clary B., Kaminski, Jim, Xiao, Sheng, Horste, Gerd Meyer Zu, Pawlak, Mathias, Kishi, Yasuhiro, Joller, Nicole, Karwacz, Katarzyna, Zhu, Chen, Ordovas-Montanes, Maria, Madi, Asaf, Wortman, Ivo, Miyazaki, Toru, Sobel, Raymond A., Park, Hongkun, Regev, Aviv, Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671820/
https://ncbi.nlm.nih.gov/pubmed/26607793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.10.068
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