Crystal packing modifies ligand binding affinity: The case of aldose reductase

The relationship between the structures of protein–ligand complexes existing in the crystal and in solution, essential in the case of fragment-based screening by X-ray crystallography (FBS-X), has been often an object of controversy. To address this question, simultaneous co-crystallization and soak...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Cousido-Siah, Alexandra, Petrova, Tatiana, Hazemann, Isabelle, Mitschler, André, Ruiz, Francesc X., Howard, Eduardo, Ginell, Stephan, Atmanene, Cédric, Van Dorsselaer, Alain, Sanglier-Cianférani, Sarah, Joachimiak, Andrzej, Podjarny, Alberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671318/
https://ncbi.nlm.nih.gov/pubmed/22752989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24136
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