Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase

We present results of combined studies of the enzyme human aldose reductase (h-AR, 36 kDa) using single-crystal x-ray data (0.66 Å, 100K; 0.80 Å, 15K; 1.75 Å, 293K), neutron Laue data (2.2 Å, 293K), and quantum mechanical modeling. These complementary techniques unveil the internal organization and...

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Hlavní autoři: Blakeley, Matthew P., Ruiz, Federico, Cachau, Raul, Hazemann, Isabelle, Meilleur, Flora, Mitschler, Andre, Ginell, Stephan, Afonine, Pavel, Ventura, Oscar N., Cousido-Siah, Alexandra, Haertlein, Michael, Joachimiak, Andrzej, Myles, Dean, Podjarny, Alberto
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538850/
https://ncbi.nlm.nih.gov/pubmed/18250329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711659105
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