The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration

Cerebral ischemia stimulates N-methyl-d-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study designs or toxicity of NMDAR antagonists. Acamprosate is an indirect NMDAR antagon...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Doeppner, Thorsten R, Pehlke, Jens R, Kaltwasser, Britta, Schlechter, Jana, Kilic, Ertugrul, Bähr, Mathias, Hermann, Dirk M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671132/
https://ncbi.nlm.nih.gov/pubmed/26219600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.179
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