Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression

Although there is great interest in harnessing the immunosuppressive potential of FOXP3(+) regulatory T cells (Tregs) for treating autoimmunity, a sizeable knowledge gap exists regarding Treg fate in human disease. In juvenile idiopathic arthritis (JIA) patients, we have previously reported that aty...

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Bibliographic Details
Published in:J Immunol
Main Authors: Bending, David, Giannakopoulou, Eirini, Lom, Hannah, Wedderburn, Lucy R.
Format: Artigo
Language:Inglês
Published: AAI 2015
Subjects:
Clinical and Human Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671090/
https://ncbi.nlm.nih.gov/pubmed/26561546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500391
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