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Hypomethylation at the Regulatory T Cell–Specific Demethylated Region in CD25(hi) T Cells Is Decoupled from FOXP3 Expression at the Inflamed Site in Childhood Arthritis
The maintenance of FOXP3 expression in CD25(hi) regulatory T cells (Tregs) is crucial to the control of inflammation and essential for successful Treg transfer therapies. Coexpression of CD25 and FOXP3 in combination with a hypomethylated region within the FOXP3 gene, called the Treg-specific demeth...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
AAI
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157061/ https://ncbi.nlm.nih.gov/pubmed/25092890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400599 |
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