MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling

How BMP signaling integrates into and destabilizes the pluripotency circuitry of human pluripotent stem cells (hPSCs) to initiate differentiation into individual germ layers is a long-standing puzzle. Here we report muscle segment homeobox 2 (MSX2), a homeobox transcription factor of msh family, as...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Wu, Qingqing, Zhang, Leisheng, Su, Pei, Lei, Xiaohua, Liu, Xin, Wang, Hongtao, Lu, Lisha, Bai, Yang, Xiong, Tao, Li, Dong, Zhu, Zhengmao, Duan, Enkui, Jiang, Erlie, Feng, Sizhou, Han, Mingzhe, Xu, Yuanfu, Wang, Fei, Zhou, Jiaxi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670987/
https://ncbi.nlm.nih.gov/pubmed/26427715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.118
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