Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with epitope loss occur in 10% to 20% of pediatric responders. We detected hemizygous deletions spanning the CD19 locus and de novo f...

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Udgivet i:Cancer Discov
Main Authors: Sotillo, Elena, Barrett, David M., Black, Kathryn L, Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R., Martinez, Nicole M., Harrington, Colleen T., Chung, Elaine Y., Perazzelli, Jessica, Hofmann, Ted J., Maude, Shannon L., Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F., Melenhorst, Jan J., Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W., Maris, John M., Grupp, Stephan A., Thomas-Tikhonenko, Andrei
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670800/
https://ncbi.nlm.nih.gov/pubmed/26516065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1020
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