Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

INTRODUCTION: Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, fibro-inflammatory cholangiopathy. The role of the microbiota in PSC etiopathogenesis may be fundamentally important yet remains obscure. We tested the hypothesis that germ-free (GF) mdr2(−/−) mice develop a distinct PSC ph...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hepatology
Prif Awduron: Tabibian, James H., O’Hara, Steven P., Trussoni, Christy E., Tietz, Pamela S., Splinter, Patrick L., Mounajjed, Taofic, Hagey, Lee R., LaRusso, Nicholas F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670294/
https://ncbi.nlm.nih.gov/pubmed/26044703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27927
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