Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450

Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-o...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cerella, C, Muller, F, Gaigneaux, A, Radogna, F, Viry, E, Chateauvieux, S, Dicato, M, Diederich, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669823/
https://ncbi.nlm.nih.gov/pubmed/26068790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.134
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