The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

The selenoprotein thioredoxin reductase 1 (TrxR1) has several key roles in cellular redox systems and reductive pathways. Here we discovered that an evolutionarily conserved and surface-exposed tryptophan residue of the enzyme (Trp114) is excessively reactive to oxidation and exerts regulatory funct...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Xu, J, Eriksson, S E, Cebula, M, Sandalova, T, Hedström, E, Pader, I, Cheng, Q, Myers, C R, Antholine, W E, Nagy, P, Hellman, U, Selivanova, G, Lindqvist, Y, Arnér, E S J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669772/
https://ncbi.nlm.nih.gov/pubmed/25611390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.574
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