Thioredoxin Txnl1/TRP32 Is a Redox-active Cofactor of the 26 S Proteasome

The 26 S proteasome is a large proteolytic machine, which degrades most intracellular proteins. We found that thioredoxin, Txnl1/TRP32, binds to Rpn11, a subunit of the regulatory complex of the human 26 S proteasome. Txnl1 is abundant, metabolically stable, and widely expressed and is present in th...

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Main Authors: Andersen, Katrine M., Madsen, Louise, Prag, Søren, Johnsen, Anders H., Semple, Colin A., Hendil, Klavs B., Hartmann-Petersen, Rasmus
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685705/
https://ncbi.nlm.nih.gov/pubmed/19349277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900016200
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