A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3. Necroptotic cell death contributes to the pathophysiology of several disorders involving tissue damage, including myocardial infarction, stroke and ischemia-re...

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Vydáno v:Cell Death Dis
Hlavní autoři: Fauster, A, Rebsamen, M, Huber, K V M, Bigenzahn, J W, Stukalov, A, Lardeau, C-H, Scorzoni, S, Bruckner, M, Gridling, M, Parapatics, K, Colinge, J, Bennett, K L, Kubicek, S, Krautwald, S, Linkermann, A, Superti-Furga, G
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669708/
https://ncbi.nlm.nih.gov/pubmed/25996294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.130
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