Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult

To explore the general requirement of endothelial mTORC2 during embryonic and adolescent development, we knocked out the essential mTORC2 component Rictor in the mouse endothelium in the embryo, during adolescence and in endothelial cells in vitro. During embryonic development, Rictor knockout resul...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Aimi, Fabio, Georgiopoulou, Stavroula, Kalus, Ina, Lehner, Fabienne, Hegglin, Alica, Limani, Përparim, Gomes de Lima, Vinicius, A. Rüegg, Markus, Hall, Michael N., Lindenblatt, Nicole, Haas, Elvira, Battegay, Edouard J., Humar, Rok
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669526/
https://ncbi.nlm.nih.gov/pubmed/26635098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17705
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