Prospective Multicenter Phase II Trial of Systemic ADH-1 in Combination With Melphalan via Isolated Limb Infusion in Patients With Advanced Extremity Melanoma

PURPOSE: Isolated limb infusion (ILI) with melphalan (M-ILI) dosing corrected for ideal body weight (IBW) is a well-tolerated treatment for patients with in-transit melanoma with a 29% complete response rate. ADH-1 is a cyclic pentapeptide that disrupts N-cadherin adhesion complexes. In a preclinica...

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Vydáno v:J Clin Oncol
Hlavní autoři: Beasley, Georgia M., Riboh, Jonathan C., Augustine, Christina K., Zager, Jonathan S., Hochwald, Steven N., Grobmyer, Stephen R., Peterson, Bercedis, Royal, Richard, Ross, Merrick I., Tyler, Douglas S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2011
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4668281/
https://ncbi.nlm.nih.gov/pubmed/21343562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.1224
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