A Phase 1 Study of Systemic ADH-1 in Combination With Melphalan via Isolated Limb Infusion in Patients With Locally Advanced In-Transit Malignant Melanoma

BACKGROUND: Isolated limb infusion with melphalan is a well-tolerated treatment for patients with in-transit extremity melanoma with an approximately 30% complete response (CR) rate. ADH-1 is a cyclic pentapeptide that disrupts N-cadherin adhesion complexes and when given systemically in a preclinic...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Beasley, Georgia M., McMahon, Nicole, Sanders, Gretchen, Augustine, Christina K., Selim, Maria A., Peterson, Bercedis, Norris, Robin, Peters, William P., Ross, Merrick I., Tyler, Douglas S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533793/
https://ncbi.nlm.nih.gov/pubmed/19637344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.24509
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